The evidence
Medical Studies
Penis enlargement is increasingly in demand, and the methods divide into surgical, non-surgical (filling) and mechanical. Here is a selection of the peer-reviewed literature on hyaluronic-acid filler for girth augmentation.
Selected studies
What the research shows.
Injection of hyaluronic acid into the penis glans
Injecting HA into the dermis of the glans was straightforward, showed long-term residence, and produced a high satisfaction rate — suggesting injectable filler is a safe, effective material for soft-tissue augmentation of the glans in patients with a small penis head.
Use of Macrolane VRF 30 in hemicircumferential penis enlargement
A retrospective review of 83 patients treated with either an HA-injection technique or lipofilling (fat) between 2007 and 2011. Circumferential enlargement from both techniques ranged from 3.2 to 4.5 cm. No complications were seen with HA, whereas eight lipofilling patients developed granuloma and one had fat necrosis. The vast majority (72) were "very satisfied". The authors conclude that hemicircumferential enlargement with HA filler meets the criteria of an ideal, non-surgical technique — though results are durable but not definitive, so repeat treatment is needed.
Nonsurgical medical penile girth augmentation: experience-based recommendations
Notes that penile augmentation is increasingly sought yet remains controversial, with limited standardised recommendations and outcome data — underlining the need for safe, effective, minimally invasive procedures to be developed and reported.
Psychological and psychosexual outcomes of non-surgical girth augmentation
Of 25 men assessed 1–12 months after treatment (mean 6.6 months), most were satisfied with size, appearance and function. There were statistically significant improvements in genital self-image (P<0.001) and self-esteem (P=0.008), and a reduction in penile-focused body-dysmorphic symptoms (P=0.002). Interviews highlighted higher satisfaction with girth, increased self-confidence, and increased sexual confidence with some mixed relationship impacts.
Current hyaluronic-acid formulations developed specifically for penis enlargement are more durable than older varieties, acting as a scaffold that can create a degree of new tissue. Note that nothing about the body is truly "permanent" — filler is gradually metabolised, and top-up procedures maintain the result. Individual results will vary from person to person.
Questions about the evidence?
Dr Anderson is happy to talk through the research in a private consultation across New Zealand.
About this page
Last reviewed on 28 July 2026.
Written and medically reviewed by Dr Brent Anderson (MBChB), Fellow of the New Zealand Society of Cosmetic Medicine, who leads Androfill in New Zealand.
Information on this page is drawn from the published literature on hyaluronic-acid penile filler and from Androfill’s clinical experience since 2012. It is general information, not a substitute for a consultation — your own suitability, options and risks must be assessed in person by your doctor.